Saudi Arabian clubs dominated the group stage, with Al Hilal, Al Ahli, and Al Nassr all qualifying for the quarter-finals.
2024 tournament runners-up Yokohama F. Marinos from Japan lost just one match in the league phase but must overcome poor domestic form to win the competition.
Qatar’s Al Sadd are seeking their first AFC Champions League since 2011.
The single-leg knockout matches will be played in a condensed format in Jeddah from 25 April, with the final on Saturday 3 May.